Testosterone Replacement Therapy Side Effects

Testosterone therapy is a safe and effective way to treat men and women suffering from testosterone deficiencies. However, like any prescription medication, testosterone has some possible side effects.

Patients diagnosed with low testosterone should not allow the possible side effects of testosterone therapy to keep them from using testosterone if recommended for you by your doctor.

The following list of potential side effects of testosterone replacement is not intended to frighten you in any way or to imply that using testosterone in the way it has been prescribed for you is risky or unsafe. We present this page merely for educational purposes and so that all patients considering testosterone replacement are aware of the side effects listed by law by the drug’s manufacturers.

Almost all of our patients have a good experience with testosterone replacement therapy and go through the course of treatment with few if any side effects or issues. 

Testosterone replacement therapy is the standard of care for patients diagnosed with testosterone deficiency.   

What Are the Side Effects of Testosterone Replacement Therapy?

Testosterone Replacement Therapy Side Effects

Like any drug or medical procedure, testosterone therapy has some potential side effects. There are common side effects of testosterone therapy and some less common side effects of testosterone therapy. There are also some potential side effects of testosterone that are specific to women.

Again, understand, even those side effects listed as "common" side effects of testosterone replacement does not mean that every patient will experience any or all of them. They are just the side effects that have been reported most often during clinical trials during the approval process of prescription testosterone.

The brand names of testosterone that we prescribe at our clinics have all gone through that process and are approved for use and generally recognized as safe by the US Food and Drug Administration.

Common Testosterone Therapy Side Effects

We have found that the safest and most effective way to receive testosterone therapy is via injection. Some of the reported possible side effects of testosterone injections for men or women include:

  • Breast swelling
  • Headache, anxiety
  • Increased facial or body hair growth, male-pattern baldness
  • Increased or decreased interest in sex
  • Numbness or tingly feeling
  • Pain or swelling where the medicine was injected.

In patients using testosterone gels or creams, in addition to the possible side effects listed above, there is also an issue with "cross-contamination" of people coming in contact with the skin or clothing where the testosterone has been applied.

Children and pregnant women, in particular, need to avoid coming into contact with such testosterone creams and gels. This is another reason why our doctors prefer to prescribe testosterone injections rather than such topical applications for testosterone replacement.

Less Common Testosterone Therapy Side Effects 

Some of the rare or less common side effects of testosterone therapy for men or women include:

  • Chest pain, sudden cough, wheezing, rapid breathing, coughing up blood;
  • Pain, swelling, warmth, or redness in one or both legs;
  • Nausea or vomiting
  • Changes in skin color
  • Priapism (ongoing erection of the penis)
  • Impotence, ejaculation problems, decreased amounts of semen, decrease in testicle size
  • Male-pattern hair growth (such as on the chin or chest)
  • Hoarse voice
  • Painful or difficult urination
  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Indigestion
  • Trouble breathing
  • Heart palpitations
  • Pain in chest
  • Pressure in chest
  • Dark-colored or blood in urine or stool
  • Ulcers in the mouth or on gums
  • Stomach pain, constipation, increased thirst or urination, muscle pain or weakness, joint pain, confusion, and feeling tired or restless
  • Upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)

This is not a complete list of possible side effects. You should consult with your doctor for medical advice about side effects.

Are There Specific Testosterone Side Effects for Women?

Women’s bodies make and need testosterone as well. Women can also suffer from low testosterone and therefore are treated with testosterone replacement. Women may experience any of the side effects of testosterone therapy previously listed. There are also some potential side effects of testosterone therapy that are specific to women.

Some of the possible side effects of testosterone replacement unique to women include:

  • Changes in menstrual periods
  • Deepening of the voice
  • Excessive hair growth, particularly on the face
  • Enlargement of the clitoris, a part of the outside of a woman’s genitals
  • Enlarged clitoris
  • Hot flashes
  • Night sweats
  • Fluid retention

Why Do Side Effects are Occur With Testosterone Therapy?

Almost all of the time that someone experiences side effects from testosterone, it is because they are using it illegally without a legitimate doctor’s prescription in a manner other than the way it has been prescribed for them.

Any drug, even common over-the-counter medications such as aspirin or cold remedies, have a long list of possible side effects. Some of the listed side effects occur because different people have different tolerances to any given medication. You can take a drug, even one that has been prescribed for you, and have some negative reactions, whereas even someone as close to you as a brother or sister can take the exact same medication and experience little or no issues or side effects.

That is exactly why drugs like testosterone must list all of their potential side effects. Anyone can have anything on the list. It certainly does not mean that everyone will.

That all having been said, there are some patients who should not take testosterone. According to contraindication provided by the drug companies who make prescription testosterone, “men who have prostate cancer or breast cancer should not take testosterone replacement therapy.

Nor should men who have severe urinary tract problems, untreated severe sleep apnea, or uncontrolled heart failure. All men considering testosterone replacement therapy should undergo a thorough prostate cancer screening — a rectal exam and PSA test — prior to starting this therapy.”

In addition, according to most testosterone manufacturers, you should not receive testosterone therapy if you are allergic to testosterone or if you have:

  • A serious heart condition
  • Severe liver disease
  • Severe kidney disease
  • If you are pregnant or may become pregnant.

As with any prescription drug or medical procedure, testosterone can have some side effects.

How to Avoid Adverse Effects

Adverse Effects

You can avoid most of the side effects of testosterone therapy by working with a reputable doctor. Like the treatment you receive for any serious medical treatment, the doctor you choose to provide your therapy is instrumental in the outcome of your recovery.

If you get your prescription for testosterone from a skilled and experienced provider of testosterone therapy, you will likely have a very good experience and have very few, if any, side effects from your testosterone replacement treatments. You should only work with a testosterone doctor or testosterone clinic that has a proven track record for safety. You should look for a provider of testosterone therapy that is known to carefully monitor their patients and who treats every case as an individual.

Furthermore, to minimize any potential side effects of testosterone therapy, it is essential that you follow all of your doctor’s instructions. Never exceed your recommended dose. Only take the number of injections you have been prescribed per week. If you do experience any side effects, they can usually be fixed by simply adjusting your dose of testosterone.

The Benefits of Testosterone Replacement Vs. the Potential Side Effects

The many provide benefits of testosterone injections for men with low testosterone far outweigh on possible risks or potential side effects. The benefits you can expect to experience from testosterone injections include:

  • Loss of belly fat
  • Increase energy and vitality
  • Increased ability to build lean muscle
  • Improved libido and sexual performance
  • Improved cognition and memory
  • Improved mood
  • Return to more regulated sleep
  • Improved eyesight
  • Healthier skin and reduced appearance of lines and wrinkles
  • Stronger, healthier hair

When you measure the number of known benefits of testosterone therapy against the remote possibilities of side effects, the many benefits of testosterone replacement therapy far outweigh the potential risks.

And always keep in mind that our goal is to ensure that your experience with testosterone therapy is a good one. Our doctors and staff will do everything in their power to ensure that you go through the course of your program of testosterone replacement with little or no discomfort or issues.

We have found that even if our testosterone replacement patients do experience some side effects, those can usually be mitigated with a simple adjustment of their medication. After that, they go on to achieve all of the benefits of testosterone replacement without issue.

Patients with low testosterone should not let the possible side effects of testosterone therapy deter them from using testosterone if your doctor recommends it.

Now that you know quite a bit more about the potential side effects of testosterone therapy, why not take a minute to contact us and learn more about how testosterone replacement therapy can improve your quality of life.

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